Meet some of the amazing characters and events that have shaped the world of science and medicine in History Heroes’ 500 piece jigsaw puzzle. History Heroes Medicine Makers takes you on a fantastically illustrated journey through 200 years of fast changing medicine and science. Piece together the puzzle and the journey in the shape of a DNA timeline from 1756 when medicine was still based on guesswork and superstition and Joseph Fry sold chocolate as a tonic from his apothecary. Packed with facts, the jigsaw leads you to 1953 when Crick and Watson determined the double-helix structure of DNA. Meet 14 highlighted History Heroes along the way, such as Edward Jenner, Florence Nightingale and Mary Seacole, Louis Pasteur, Elizabeth Garrett Anderson, Marie Curie, Alexander Fleming and Rosalind Franklin, who shaped and changed our knowledge of medicine and health together with some of the major global, scientific and technological events that helped shape that journey too.